Anti-HEPACAM EPR11217 antibody （ab172635）抗肝細胞黏附分子抗體

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Anti-HEPACAM [EPR11217] antibody (ab172635)抗肝細胞黏附分子抗體產品信息：

• Product nameAnti-HEPACAM [EPR11217] antibody
• Description

  Rabbit monoclonal [EPR11217] to HEPACAM

• Tested applicationsWB, ICC/IF
• Species reactivityReacts with: Human

  Does not react with

  Mouse, Rat
• Immunogen

  Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human HEPACAM aa 50-150 (Cysteine residue). The exact sequence is proprietary.
  Database link: Q14CZ8

• Positive control
  • Human fetal kidney, fetal liver, fetal brain and stomach lysates; HepG2 cells.
• General notes

  Produced under U.S. Patent No. 5,675,063.

Properties

• FormLiquid
• Storage instructionsShipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
• Storage bufferpH: 7.2
  Preservative: 0.01% Sodium azide
  Constituents: 50% Glycerol, 49% PBS, 0.05% BSA
• PurityTissue culture supernatant
• ClonalityMonoclonal
• Clone numberEPR11217
• IsotypeIgG
• Research Areas
  • Signal Transduction
  • Cytoskeleton / ECM
  • Cell Adhesion
  • Cell Adhesion Molecules
  • Liver
  • Cancer
  • Invasion/microenvironment
  • ECM
  • Cell adhesion
  • Other

Applications

Our Abpromise guarantee covers the use of ab172635 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

• Application notesIs unsuitable for ,IHC-P or IP.

Target

• FunctionInvolved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation.
• Sequence similaritiesContains 1 Ig-like C2-type (immunoglobulin-like) domain.
  Contains 1 Ig-like V-type (immunoglobulin-like) domain.
• DomainThe cytoplasmic domain plays an important role in regulation of cell-matrix adhesion and cell motility.
• Post-translational
  modificationsN-glycosylated.
• Cellular localizationCytoplasm. Membrane. In MCF7 breast carcinoma and hepatic Hep3B and HepG2 cell lines, localization of HEPACAM is cell density-dependent. In well spread cells, localized to punctate structures in the perinuclear membrane, cytoplasm, and at cell surface of protusions. In confluent cells, localized predominantly to the cytoplasmic membrane, particularly in areas of cell-cell contacts. Colocalizes with CDH1.

• Database links

  • Entrez Gene: 220296 Human
  • Omim: 611642 Human
  • SwissProt: Q14CZ8 Human
  • Unigene: 159863 Human

Anti-HEPACAM [EPR11217] antibody images

• 

  Immunocytochemistry/ Immunofluorescence - Anti-HEPACAM [EPR11217] antibody (ab172635)

• Immunofluorescent analysis of HepG2 cells labeling HEPACAM with ab172635 at 1/250 dilution. DAPI nuclear staining (blue).

公司介紹：

    Abcam位于英國的劍橋科學園，成立于1998年，專門生產和分銷研究型抗體。主要創立人Jonathan Milner和實驗室同事構思成立一間了解科研人員需要的網上抗體公司，理念是Abcam銷售質量高的抗體，并提供zui全面、誠實、時新的說明書，快速的送貨服務，及高效率的顧客和服務。我們的在線目錄(www.abcam.cn) 已有差不多100,000種抗體和試劑，并不斷添加，供應予百多個國家。Abcam于2005年11月在倫敦證券交易所上市，在美國馬薩諸塞州、日本東京及香港均設有分公司。

    Abcam 一直致力加強產品線，為使研究員更容易找到蛋白質研究試劑產品，在2011并購了美國的MitoSciences公司，加強了免疫分析方面的產品供應；同年也并購了英國的Ascent Scientific 公司，開展了生化試劑的供應。在2012年，Abcam并購了美國的Epitomics 公司，成為一家有的RabMAbs® 供應商。

    Abcam 的 目標是給世界上的抗體建立zui大的在線目錄，為各地科學家提供*產品，成為各國科學界的重要伙伴。我們為所有產品提供來使客戶獲得預期的結 果。為提供高質量的抗體來指向盡可能多的靶蛋白，我們盡所能在盡可能多的應用和物種中檢測每種抗體。我們相信誠信才是上策，在我們的上會發布有關我們 每一種產品的盡可能多的信息。

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