GDC-0941（PI3 Kinase Inhibitor）,（PI3 激酶抑制劑）

產品信息

Hedgehog（Hh） 信號通路調節胚胎發育和成體許多組織器官干細胞的自我更新與增殖。然而，那些在正常發育過程中受到Hh信號通路調節的組織器官，在該信號通路異常時常常發 生腫瘤。這些腫瘤包括肝癌、神經膠質瘤、基底細胞癌、橫紋肌肉瘤、胰腺癌、小細胞肺癌、胃癌、結腸癌、前列腺癌、黑色素瘤和多發性骨髓瘤等。

GDC-0941 is a potent inhibitor of PI3Kα, PI3Kβ, PI3Kδ and PI3Kγ with IC50 of 3 nM, 33 nM, 3 nM and 75 nM, respectively. Administration of GDC-0941 in animals displays significant inhibitory effect against established human cancer xenografts. It is currently in clinical trials.

PI3K inhibitors have been used for differentiation of pluripotent stem cells

Purity:
Greater than 99% as determined by LC/MS analysis. LC/MS and/or NMR data available upon request.

Biological Activity:
Not determined.

重慶市華雅干細胞技術有限公司